Abstract
Several LY294002-GM heterodimers were synthesized with the intent of modulating their activity in the presence of hsp90 and thereby creating selective inhibitors of PI3K and PI3K-related family.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Ataxia Telangiectasia Mutated Proteins
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Benzoquinones
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Cell Cycle Proteins
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Chromones / chemistry
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Chromones / pharmacology*
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DNA-Activated Protein Kinase
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DNA-Binding Proteins*
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Dimerization
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HSP90 Heat-Shock Proteins / chemistry
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HSP90 Heat-Shock Proteins / metabolism
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Inhibitory Concentration 50
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Lactams, Macrocyclic
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Morpholines / chemistry
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Morpholines / pharmacology*
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Phosphoinositide-3 Kinase Inhibitors*
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Protein Serine-Threonine Kinases / antagonists & inhibitors*
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Protein Serine-Threonine Kinases / chemistry
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Protein Serine-Threonine Kinases / metabolism
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Quinones / chemistry
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Quinones / pharmacology*
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Tumor Suppressor Proteins
Substances
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Benzoquinones
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Cell Cycle Proteins
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Chromones
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DNA-Binding Proteins
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HSP90 Heat-Shock Proteins
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Lactams, Macrocyclic
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Morpholines
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Phosphoinositide-3 Kinase Inhibitors
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Quinones
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Tumor Suppressor Proteins
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
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Ataxia Telangiectasia Mutated Proteins
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DNA-Activated Protein Kinase
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Protein Serine-Threonine Kinases
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geldanamycin